Wednesday, 3 February 2021

Egg Donation

Egg donation is a procedure in which a donor woman donates her fertile eggs to a recipient woman to help her conceive through assisted reproduction technology. It typically involves retrieval of eggs from the donor, fertilizing them in a laboratory, and then transferring the healthy embryos into the recipient’s uterus. In vitro fertilization (IVF) using donor eggs have proved beneficial for women who cannot conceive with their own eggs due to reasons such as:

  •     Premature ovarian failure
  •     Poor quality of eggs
  •     Advanced age
  •     Ovarian diseases
  •     Ovaries surgically removed
  •     Risk of inheritable genetic disease

The Procedure

The donor receives hormonal injections to induce ovulation and allow multiple eggs to mature at the same time. The doctor retrieves the mature eggs using an ultrasound guided needle and will fertilize these eggs in the laboratory using the recipient’s partner’s sperm or donor sperm. Once the eggs are fertilized, the embryos are transferred into the recipient’s uterus and monitored closely for pregnancy. After a successful implantation, the recipient carries the developing baby through the full term of the pregnancy and childbirth. In a fresh transfer, the menstrual cycles of the donor and recipient are synchronized using medications while in frozen transfer, the embryos are frozen and transferred at a later time.

Thousands of couples have become parents by opting for egg donation as an infertility treatment. It has been a boon for women to mother a child, experiencing all the joys of pregnancy and motherhood.

Blog Reviewed By: Dr. Soumyaroop Dash
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Thursday, 12 November 2020

ART - IVF (Preparatory Phase)

ART or Assisted Reproductive Technology includes all the procedures where the eggs are surgically retrieved from a woman’s ovaries and combined with the sperms in a laboratory setting to transfer the embryo to the woman’s uterus. IVF or In Vitro Fertilization is a common method of assisted reproduction where the sperms and eggs are combined in a laboratory dish outside of the body. IVF is used to treat women with blocked, damaged, or absent fallopian tubes and endometriosis. It is also used in cases that concern male factors and when a couple’s infertility is unexplained. Typically an IVF cycle involves the following steps:

  • Ovarian stimulation
  • Retrieval of eggs from the ovary or ovaries
  • Fertilization
  • Embryo culture
  • Embryo transfer into the uterus
  • Support the uterine lining with medications to aid pregnancy

Let us now discuss the Preparatory Phase in detail:


To prevent premature ovulation and maximize the number of eggs available for retrieval, injections containing GnRH agonist are given along with oral contraceptive pills to allow more flexibility in the timing of the cycle and reduce the chance of development of ovarian cysts. A transvaginal pelvic ultrasound is also done during this time to look out for the presence of cysts.

Ovarian Stimulation and Monitoring

In this phase, the ovaries are stimulated with daily injections of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) that aid your ovaries in producing multiple mature eggs at once. Retrieving multiple eggs will improve your chances of success.

Final Oocyte Maturation

Once your eggs are ready for retrieval, a single injection of human Chorionic Gonadotropin (hCG) is required to induce the final maturation of eggs, 36 hours before the egg retrieval procedure.

Once the eggs are successfully retrieved, they are incubated in specialized media so that they can fertilize and start developing into embryos. It is very important to be compliant with the treatment and doctor’s instruction during the preparatory phase for a successful pregnancy.

Blog Reviewed By: Dr. Soumyaroop Dash
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Monday, 20 July 2020

Early pregnancy - concerns and complications

Early pregnancy’ is a very misleading phrase, as it can refer either to missed signs of pregnancy in women or to pregnancy among females who have not yet reached adulthood, called teenage pregnancy. We will be referring to the first one.

Most pregnancies progress without any problems, but it has been seen that about 8% involve complications that if ignored/untreated may harm the mother and the child.

For most women, a missed menstrual period is often the first sign of pregnancy. But, in today’s hectic world, women have been known to miss this sign, leading to miscalculation in tracking the pregnancy later on. 

Early pregnancy can be a worrying time for women and following are some of the concerns and complications that may arise. 


Blood spots are normal, but heavy bleeding could be a sign of miscarriage. If there is bleeding and cramps similar to that of normal menstrual periods, then it could be leading to a miscarriage. However, most women do not have any problems, and go on to have a healthy baby. But, it would be best to consult your doctor without fail.


A miscariage occurs when a pregnancy stops proceeding and the pregnancy tissue is ejected out of the body and it is common in the first few weeks. As said earlier, periods-like pain, cramps and bleeding often precede a miscarrige. Usually no treatable cause can be found, though it does occur in more older women than the young.


Normally a fertilized egg goes through the fallopian tube and reaches the uterus, where it settles and starts growing. The uterus has the ability to stretch and grow, but the fallopian tube does not. When an egg stays and grows inside the fallopian tube it is called an ectopic pregnancy and it is a very dangerous condition as it can cause the tube to stretch and burst leading to internal bleeding and urgent remedial surgery. One to two of every hundred pregnancies are ectopic.


This is extremely rare, found in only around one in thousand pregnancies. Here there is an unusual and rapid  growth of the placenta which prevents the fetus from growing and leads to a miscarriage. It is often discovered in the first three months.

Blog Reviewed By: Dr. Soumyaroop Dash
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Saturday, 16 May 2020

Lifestyle modifications in treating infertility

Infertility is the inability to reproduce by natural means. This is not a natural state of affairs. 
In humans, if even after a year of intercourse without contraception, no pregnancy is seen, then, it is considered to be a problem of infertility.


Of all the causes of infertility in modern times, lifestyle is an important one, and making drastic changes to it can bring dramatic results.

Improving male fertility:
  1. Lose body weight. It has been found that obesity can cause hormonal changes that can affect fertility. Low sperm count and sluggish sperms have also been attributed to obesity.
  2. Say NO TO DRUGS. Especially the so-called ‘recreational ones’. They can reduce the number and quality of the sperm and some steroids can shrink the size of the human testicle. If you have to take prescription drugs or supplements, do check with your doctors on their effects.
  3. Practice safe sex. This is especially true for those with multiple partners. Sexually transmitted diseases can have serious implications on fertility like fragmentation of sperm DNA.
  4. Stop smoking and reduce alcohol consumption. One does not have to explain why.
  5. Try not to get overheated, especially around the scrotum. Loose clothing is advised.
Improving female fertility:
  1. Maintain a healthy body weight, neither over nor under. Healthy body mass helps in maintaining healthy ovulation.
  2. Reduce caffeine consumption. 
  3. Stop smoking.
  4. Practice safe sex. As in males, sexually transmitted diseases cause problems, like damage to the fallopian tube and uterus.

For improving both male and female:
  1. Exercise regularly but in moderation.
  2. Stress cannot be avoided, so, acknowledge and manage it.
  3. Mange or tweak your diet. Consume good, nutritious, freshly cooked food. Avoid packaged food as far as possible.

Blog Reviewed By: Dr. Soumyaroop Dash
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Monday, 16 March 2020

Radiofrequency for perfection

The advancement of technology has helped all the industries equally with outstanding facilities. Radio Frequency Identification  (RFID) is the first of its kind that provides greater assurance and peace of mind to parents of the newborns.

Why RFID for couples? 

Radio Frequency Identification (RFID) is considered to be a non-contact based wireless communication technology that helps to identify specific targets, read, and write critical data through wireless signals. These will not cause any adverse effects on the human body or cellular components. RFID helps to pass through liquids; hence is used in the field of medicine, human body implants, and biological research due to its stability and security. 

Some hospitals use 'match intelligent verification system,' which is an integrated intelligent system based on RFID technology. This can be used in the IVF laboratories for operation verification and process management scenarios. These provide excellent security, ease of use, and broad compatibility. 

The major reason for hospitals using RFID would be for the following:
  • Helps to eliminate mismatch and reassuring 
  • Provides customized SOP and full traceability 
  • Ensures high efficiency 
  • Easy and stable to use 
  • Safeguards every step of the IVF operation 
  • Chip is non-toxic and non-volatile hence no harm on anyone

Functioning of RFID 

RFID is the first of its kind and is a sided sensing mechanism to monitor operation area. At times, when different couples' samples are detected, the match system will send warning signs. The hospital will provide an RFID ID card to the patients who enter the cycle, which will have unique identification information. 

There will be a blank chip that is pre-pasted on the prepared vessels and test tubes for further identification. Generally, in each workspace of the labs, the match system will transfer the information of the patients from the last chip to the next blank chip to be used. The match system will help in actively scanning and confirming that there is no mismatch in the particular area or the workspace and automatically prompts further operational steps or procedures. 

However, if the same workspace detects samples of varied couples, the system will automatically interrupt the operation and leave the signal for the operator. Before embryo transfer, the doctor will ensure the system to scan the patient's ID card, matching the embryo to be transferred. This matching system can also help to track and check the sample information on the frozen and recovery process. 

At Srishti Assisted Fertility & Advanced Laparoscopy Centre, the doctor and team provide the best service with the help of RFID to prevent mismatch in pregnancy.

Blog Reviewed By: Dr. Soumyaroop Dash
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Thursday, 27 February 2020

Social Egg Freezing for Fertility Preservation

There are several aspects connected to fertility and conceiving. Age, financial stability, lifestyle, and psychological aspects could be considered to play a major role. Egg freezing resolves infertility issues and helps to begin a new family. 

Egg freezing is a method by which the eggs are stored to preserve fertility and allows them to conceive later. This is considered by women who have issues with conceiving due to various reasons. It is recommended to consult the doctor on time so as to avoid further complications regarding fertility. The doctor will suggest the required tests before proceeding with the egg freezing procedure. 

Egg freezing process

Each cycle develops eggs in the ovaries and 1 egg would get matured and released through ovulation. Whereas, during the IVF period, the egg-freezing process allows all the eggs to mature.

Stimulation of your ovaries - hormone medications would be provided for 10-12 days to help stimulate ovaries. The doctor would monitor the progress through blood tests and ultrasound. 

Egg collection - sedation or pain medication would be given before the process. The eggs would be collected with the help of a thin needle that is inserted through the vagina. This procedure would take 10-15 minutes. The mature eggs will be frozen either using vitrification or snap freezing methods. 

Using the frozen eggs - the doctor will inform the patient about the right time to use the frozen eggs. The frozen eggs are thawed or unfrozen by removing from the freezing solution and warming them up to 37-degree celsius. The doctor would then inject sperm into the egg (ICSI) for fertilization and the embryo would be transferred to the uterus. 

Know the success of egg freezing

Mainly, there are two factors that define the success of the egg freezing process. The number of frozen eggs and the age of the woman would be mainly taken into consideration. As age increases, one might require more eggs to get the expected result.

For additional assistance on high-risk pregnancy, schedule an appointment at Srishti Hospital. They provide the required resources and support for egg freezing and related services.

Blog Reviewed By: Dr. Soumyaroop Dash
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Friday, 6 December 2019

The connection between thyroid and infertility

The human body and its glands are interconnected to various functions. At times the thyroid gland can affect women's health,  especially when it is an underactive thyroid gland. This could lead to fertility issues as certain hormones cannot be produced with hypothyroidism. 

When the thyroid levels are low, it will affect the release of an egg, which impairs fertility. Certain autoimmune or pituitary disorders, which are caused due to hypothyroidism, can also impair fertility. 

Thyroid hormone levels

Thyroid-stimulating hormone (TSH) blood test helps to identify the thyroid hormone level. TSH needs to remain at an optimal level or would have an effect on ovulation. The thyroid hormone levels have a link with the development of the fetus. It is essential to keep the iodine level also optimal as thyroid hormones are synthesized from iodine. With the help of medications, doctors can help treat the variations in TSH or iodine levels. The TSH should not be higher than 2.5 and 3.0 at the time of pregnancy. 

Hyperthyroidism - when the thyroid is overactive and excessive production of thyroid hormones can be considered to be hyperthyroidism. Graves’ disease and autoimmune diseases are common manifestations of this. By performing the TSH blood test, doctors can identify the presence of hyperthyroidism. Women tend to get irregular or infrequent periods, and men would have a low sperm count. Medications, radioactive iodine, or surgery are various ways to treat hyperthyroidism. 

Hypothyroidism - when the thyroid is underactive and produces insufficient or fewer thyroid hormones, it can be termed as hypothyroidism. Lack of iodine in the diet or autoimmune disease can lead to hypothyroidism. Reduced fertility, higher chances for miscarriage, lower infant intelligence, pre-eclampsia, premature birth, and infant death are certain issues related to hypothyroidism. A simple blood test will help identify the problem, and the supplementation with iodine or thyroxine can help treat the problem. 

Thyroid antibodies

Thyroid antibodies also have an impact on fertility. Thyroid antibodies are produced when the immune system attacks the thyroid gland by mistake. Infertile women would have the presence of thyroid antibodies in them. These antibodies lead to the risk of getting pregnant. Doctors recommend blood tests so that treatment could be initiated on time. 

Changes in lifestyle and reducing stress can always have an impact on thyroid levels. Better diet and regular exercise can also help prevent and allow thyroid levels to be normal. At Srishti Assisted Facility & Advanced Laparoscopic Center, doctors can help treat problems with thyroid before IVF.

Blog Reviewed By: Dr. Soumyaroop Dash
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